If you are on a guided African safari tour, your chances of encountering problems are minimal, since tour operators make it their business to know the areas they travel in so you are never at any undue risk.
Game Guides and Vehicles
The custom built, open, 4 x 4 safari vehicles generally used on safari, provide comfort with maximum visibility and protection. Your guide is an expert, so follow his advice and ask questions if you are unsure of anything.
You will need...
A camera is a definite must. There are places where you will not be able to get film, and down load facilities can be far apart, so bring enough film or data chips with you.